1/15/2024 0 Comments Opel scanner 1.01 71![]() ![]() PVS burden was significantly elevated in males compared to females with differing morphological time courses with age. In particular, regions with low PVS volume fraction in childhood are associated with rapid age-related PVS enlargement (e.g., temporal regions), while regions with high PVS volume fraction in childhood are associated with minimal age-related PVS alterations (e.g., limbic regions). Our results show age is associated with wider and more numerous MRI-visible PVS over the course of the lifetime with spatially-varying patterns of PVS enlargement trajectories. To this end, we characterized the influence of age, sex and cognitive performance on PVS anatomical characteristics in a large cross-sectiona cohort (~1400) of healthy subjects between 8 and 90 years of age using multimodal structural MRI data. Enlarged perivascular spaces (PVS) are considered a biomarker for vascular pathology and are observed in normal aging and neurological conditions however, research on the role of PVS in health and disease are hindered by the lack of knowledge regarding the normative time course of PVS alterations with age.
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